There is therefore great difference between the easiness of the conquest of Guiana, and the defence of it being conquered, and the West or East Indies. Guiana hath but one entrance by the sea, if it hath that, for any vessels of burden. So as whosoever shall first possess it, it shall be found unaccessible for any enemy, except he come in wherries, barges, or canoas, or else in flat-bottomed boats; and if he do offer to enter it in that manner, the woods are so thick 200 miles together upon the rivers of such entrance, as a mouse cannot sit in a boat unhit from the bank. By land it is more impossible to approach; for it hath the strongest situation of any region under the sun, and it is so environed with impassable mountains on every side, as it is impossible to victual any company in the passage. Which hath been well proved by the Spanish nation, who since the conquest of Peru have never left five years free from attempting this empire, or discovering some way into it; and yet of three-and-twenty several gentlemen, knights, and noblemen, there was never any that knew which way to lead an army by land, or to conduct ships by sea, anything near the said country. Orellana, of whom the river of Amazons taketh name, was the first, and Don Antonio de Berreo, whom we displanted, the last: and I doubt much whether he himself or any of his yet know the best way into the said empire. It can therefore hardly be regained, if any strength be formerly set down, but in one or two places, and but two or three crumsters (Dutch, Kromsteven or Kromster, a vessel with a bent prow) or galleys built and furnished upon the river within. The West Indies have many ports, watering places, and landings; and nearer than 300 miles to Guiana, no man can harbour a ship, except he know one only place, which is not learned in haste, and which I will undertake there is not any one of my companies that knoweth, whosoever hearkened most after it.

Besides, by keeping one good fort, or building one town of strength, the whole empire is guarded; and whatsoever companies shall be afterwards planted within the land, although in twenty several provinces, those shall be able all to reunite themselves upon any occasion either by the way of one river, or be able to march by land without either wood, bog, or mountain. Whereas in the West Indies there are few towns or provinces that can succour or relieve one the other by land or sea. By land the countries are either desert, mountainous, or strong enemies. By sea, if any man invade to the eastward, those to the west cannot in many months turn against the breeze and eastern wind. Besides, the Spaniards are therein so dispersed as they are nowhere strong, but in Nueva Espana only; the sharp mountains, the thorns, and poisoned prickles, the sandy and deep ways in the valleys, the smothering heat and air, and want of water in other places are their only and best defence; which, because those nations that invade them are not victualled or provided to stay, neither have any place to friend adjoining, do serve them instead of good arms and great multitudes.